The triumph on a spectacular night in Sin City was the 53rd of the triple champion's career, and sixth in a row, and came after a five-second penalty for forcing Ferrari's Charles Leclerc off track at the start and then a collision with Mercedes' George Russell.
Leclerc finished second after starting on pole position, losing and regaining the lead and then losing it again before passing Sergio Perez on the final lap to deny Red Bull a seventh one-two of the season.
The win was Red Bull's 20th in 21 races, another record for a single season, and delivered the racing that had risked being swamped in a wave of hype as Vegas hosted a grand prix for the first time since the 1980s.
--Reuters--