The Durban metro remains the most affected area, with 147 cases reported.
The disease, which primarily affects young children, causes blisters in the mouth, as well as on the hands and feet. Simelane has urged parents, teachers, and communities to take the outbreak seriously and implement strict hygiene measures.
"Our vigilance both as parents and educators is critical. But we need to do more. Every school, every home, and every community must take this outbreak seriously," she said.
She emphasised the importance of keeping sick children at home to prevent further transmission.
"To parents: Please, if your child shows symptoms, do not send them to school. We want to emphasise this: if your child shows symptoms, do not send them to school," Simelane stressed.
She also called on teachers to remain proactive in educating children about hygiene and enforcing precautionary measures in classrooms.
--ChannelAfrica--